The University was founded in 1909 as Imperial University by the Decree of Emperor Nicholas II. On June 10, 1909, the Emperor signed the "Decree on the foundation of the university in Saratov", which became the tenth University in Russia and consisted of the Medical Faculty only. Professor V.I. Razumovsky became the first university rector. He was a prominent public figure, talented surgeon, and unique scientist who is considered to be the founder of a neurosurgery school in Russia. Construction of major university buildings as well as the university clinic named after S.R. Mirotvortsev was carried out under the supervision of the talented russian architect Karl Hermann Ludwig Müffke.
In 1930, the Medical Faculty of Saratov University was transformed into an independent institution of higher education, which was known as the Medical Institute.
Specialists at research and development institutes, centres, laboratories, museums, and innovation groups at Saratov State Medical University conduct fundamental and applied scientific research. Among them are the Research Institute of Basic and Clinical Uro-Nephrology, the Central Research Laboratory, the Scientific Educational Centre for Fundamental Medicine and Nanotechnologies, the Medical Technopark, the University Publishing House, the Scientific Medical Library, the Museum of University History, and many other university divisions. Around 7000 students graduate from the University each year